Celiac Disease

Recently I discovered that I have celiac disease, an auto-immune disorder provoked by wheat gluten and similar grain proteins. Wheat, rye and barley are not tolerated by celiacs and must be avoided for life. Some are exquisitely sensitive and a trace will provoke strong symptoms; others can tolerate very small quantities of these proteins but the intolerance is never outgrown. Unfortunately many processed foods contain traces of gluten. For example some, but not all, soy sauces use wheat. Obviously this makes eating in Asian restaurants and any other place not careful with food cross- contamination a potential problem. Some bread crumbs dropped on a "gluten free" dish may be all it takes to provoke severe diarrhea and further bowel damage.

Cells lining bowel are harmed because of the body turning on itself (auto-immunity.) This can lead to chronic diarrhea, bloating, weight loss, fatigue, an unusual skin rash and malnutrition due to essential nutrients not being well absorbed. Anemia, various vitamin deficiencies and osteoporosis are all common sequelae and may be associated with depression.

Several genes have been identified as important in the development of celiac disease but many people with those genes don't develop the disease. Ireland has one of highest rates of celiac disease in the world but exact numbers are not known. In the United States the incidence is estimated at little less than 1%, with most cases undiagnosed. Celiac disease may first present at any age from infancy on, and other auto-immune diseases like type 1 diabetes and thyroiditis are not uncommon. Diagnosis is by a combination of family and medical history, blood antibody tests and small bowel biopsy. A confirmed diagnosis requires strict lifelong gluten abstinence even if symptoms are mild since progression with possible severe outcomes like cancer and lymphoma can occur.

https://en.wikipedia.org/wiki/Coeliac_disease  (British spelling of celiac)

                         Eating Patterns

More and more interest and research on health effects of eating timing has popped up in the scientific literature recently. A previous blog discussed the value of intermittent fasting, concluding that longevity and freedom from chronic disease were greatly improved by periods of fasting which can be as simple as not eating for a consecutive 12 to 16 hours daily.

The brain has a master clock which governs sleeping and waking dependent on exposure to bright light. Every other organ has a similar clock: the pancreas produces less insulin at night; the human gut and its microbiome also have a rhythm with the genes of the gut itself and its bacteria switching on and off at the same time.

People who interfere with this normal circadian rhythm by staying up too late have increases in weight, blood pressure and blood sugar. Night shift workers typically have poorer health.

More extreme periods of daily fasting have surprisingly powerful effects. Prediabetic men who are limited to only eating in a six hour window each day have improvement in blood pressure, less hunger, and less insulin secretion compared to those allowed to eat over a 12 hour window. If laboratory animals are given a poor quality diet with around the clock food access they get fat and sick. The same diet and food quantity limited to an eight hour window does not cause obesity or disease.

Significant health improvements, especially in weight and blood sugar, are seen if most calories are consumed early rather than late in the day.

A recent book, The Circadian Code, by Dr. Satchin Panda of the Salk Institute reviews his and others' research on eating patterns.

                        Milk and Sugar

Recent books examine the history and problems of two major foods.

Milk! by Mark Kurlansky is filled with arcane information that only a quiz show addict or dairy farmer could love. One of his topics is the difference between various mammalian milks. Human milk is very different than that of other species; it is the only really good food for infants. Children who are breast-fed are typically 2 to 3 inches taller, more confident and emotionally healthy, much less allergic. Their IQ is 15 to 20 points higher. In spite of this, our government recently attempted to block a United Nations plan encouraging breast-feeding world-wide. Our food manufacturers make big profits from infant formulas.

James Walton's Sugar- The World Corrupted From Slavery to Obesity is an historical, environmental and health triple header. Shortly after early European settlement in the Western hemisphere sugar production became the major business and drove most of the need for slaves. Sugar plantations created enormous wealth in Europe and the Americas, dominating policy decisions on slavery, trading and international relations. In the 21st century large amounts of land are wasted to produce high fructose corn syrup, cane and beet sugars for immense quantities of an addicting, unhealthy food used in most highly processed foods and beverages. It's a dismal story, again reflecting public policy benefitting business and harming citizens.